Signature Mutations Might be the Best Alternative Cause Defense You Never Heard Of

Posted by and on April 29, 2019

Genetic knowledge continues to increase at a rapid pace, transforming not only the practice of medicine but also toxic tort litigation. See our previous posts on this topic (e.g., here and here), our webinar, and our comprehensive white paper titled The Litigator’s Guide to Using Genomics in a Toxic Tort Case for more detailed information
Read More

New Study Identifies Potential Genetic Biomarker of Malignant Pleural Mesothelioma

Posted by on January 21, 2019

In a recently published article, Guarrera and colleagues report differential DNA methylation between malignant pleural mesothelioma (MPM) patients and cancer-free controls. These data represent some of the first evidence of detectable differences in DNA methylation in asbestos-exposed individuals with and without MPM. For asbestos defendants, these results provide support for the potential use of DNA
Read More

Wasting too much time searching for scientific articles and not enough time reading them?

Posted by on January 15, 2019

The volume of newly published scientific literature continues to grow at a staggering pace. A recent PubMed statistic indicates that the database hosts almost 29 million citations, with more than 1.3 million added in 2018 alone; a number that increased by 35% since 2013! And this accounts only for journals that are indexed by PubMed,
Read More

Malignant Mesothelioma in Women: Non-Occupational Asbestos Exposure or Genetics?

Posted by on January 9, 2019

A recent article by Marinaccio and colleagues examined gender differences and modalities of asbestos exposure in malignant mesothelioma (MM). The results are some of the first to examine gender differences in mesothelioma risk, with significantly more cases of MM attributed to occupational asbestos exposure in men than women. The author concluded that non-occupational exposure to
Read More

Malic Acid Under Fire in a Growing Number of Lawsuits and the Right Experts will be Key to Defending These Cases

Posted by on December 16, 2018

Malic acid is a versatile ingredient that is commonly found in food and dietary supplement products. Lately, malic acid has become the target of a growing number of lawsuits. Briefly, the suits allege that certain products are labeled as containing “no artificial flavors” but list malic acid as an ingredient. The suits continue by saying
Read More

Message to P/C Insurers: The Scientific Revolution is Here

Posted by on November 22, 2018

This article was co-written with William Wilt, President of Assured Research, a research and advisory firm dedicated to delivering highly customized, actionable research and analysis to insurance and investment professionals. It was adapted from their November 2018 briefing. In their February 2018 Assured Briefing warned: “Insurers need to get on board with the scientific revolution or risk being run
Read More

New Evidence Of Genetic Drivers For Mesothelioma In Persons With No Known Asbestos Exposure

Posted by on November 15, 2018

A recently published article authored by Drs. Michele Carbone, Haining Yang, and Harvey Pass (among others) is relevant to asbestos and talc defendants because it provides additional data supporting the conclusion that inherited genetic variations cause mesothelioma in some persons without any known exposure to asbestos. Most notably for asbestos and talc litigants, 57 out of the
Read More

New Paper Explores Heritable Genetic Factors Related To Mesothelioma

Posted by on October 11, 2018

A new paper by Kharazmi and colleagues present important data regarding the heritable nature of mesothelioma using epidemiological techniques to analyze the population-based Swedish Cancer Registry. The results, reported in the European Journal of Cancer, are important because the findings confirm that both genes and exposures are relevant, and on their face, appear helpful to
Read More

Advances in Interpreting Findings from BRCA1 Mutations

Posted by on September 20, 2018

An interesting new paper about the BRCA1 gene was published in the journal Nature last week (see here for a summary of the findings). The article is notable because it appears to offer some intriguing possibilities for relatively rapidly bringing even better genomic knowledge into cancer cases. In short, the article is focused on using
Read More

Courtroom Implications of New Paper On Germline (Inherited) Mutations Associated with Mesotheliomas (and Perhaps Ovarian Cancers)

Posted by on September 17, 2018

This is our second comment on a very recent paper (Panou 2018) reporting findings from a study looking for germline (inherited) variants (mutations) in persons afflicted by mesotheliomas. The paper reported results from a custom gene panel analysis of 195 genes associated with cancers to study a cohort of 198 persons, mainly persons who were
Read More